Arsenal visit Brentford in an all-Premier League affair, while Liverpool host Championship outfit Leicester City at Anfield.
Chelsea, with just one win under Mauricio Pochettino this season, face a daunting task against Roberto De Zerbi’s high-flying Brighton and Hove Albion at Stamford Bridge.
Elsewhere, Aston Villa face Everton, AFC Bournemouth welcome Stoke City to the south coast, Fulham and Norwich City meet, and West Ham United travel to Lincoln City.
Blackburn Rovers and Cardiff City battle at Ewood Park in the sole non-top-flight tie in an attempt to join the seven teams that progressed on Tuesday.
The Carabao Cup fourth-round draw goes down on Tyneside following the conclusion of Newcastle vs Man City.
Express Sport provides regular team news and score updates throughout the evening.